Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846303 | 0.82 | ALDH1A1 (0.48) | NPC1RAB9AMKNK2ALDH1A1 | |
| SCHEMBL6971996 | 0.78 | GLRA3 (0.31) | NPC1 | |
| SCHEMBL6966557 | 0.74 | RAB9A (0.42) | NPC1RAB9AMKNK2ALOX5ALDH1A1 | |
| SCHEMBL1800550 | 0.74 | NPC1 (0.42) | NPC1RAB9AALOX5ALDH1A1ALOX12 | |
| SCHEMBL183194 | 0.74 | RAB9A (0.42) | NPC1RAB9AALOX5ALDH1A1ALOX12 | |
| SCHEMBL7321755 | 0.72 | RAB9A (0.41) | NPC1RAB9AALOX5ALDH1A1ALOX12 | |
| SCHEMBL8930012 | 0.72 | RAB9A (0.41) | NPC1RAB9AALOX5ALDH1A1ALOX12 | |
| SCHEMBL6650651 | 0.72 | POLB (0.50) | NPC1RAB9AMKNK2ALOX5ALDH1A1 | |
| SCHEMBL19769133 | 0.71 | FFAR1 (0.42) | NPC1RAB9AALOX5ALDH1A1ALOX12 | |
| SCHEMBL403704 | 0.68 | CA12 (0.41) | ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | claimed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |