Sugi Predict

Sugi Predict / Compounds / SCHEMBL183194

SCHEMBL183194

SCHEMBL183194

CC(=O)c1c(C)coc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 2/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ ALOX5 P09917 1/20 0.36
▸ ALDH1A1 P00352 5/20 0.35
▸ ALOX12 P18054 1/20 0.35
▸ NPSR1 Q6W5P4 2/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ THRB P10828 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ KCNA3 P22001 3/20 0.33
▸ RECQL P46063 1/20 0.33
▸ MITF O75030 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ USP2 O75604 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6966557 0.81 RAB9A (0.42) RAB9ANPC1ALOX5ALDH1A1ALOX12
SCHEMBL1800550 0.81 NPC1 (0.42) RAB9ANPC1ALOX5ALDH1A1ALOX12
SCHEMBL6650651 0.79 POLB (0.50) RAB9ANPC1ALOX5ALDH1A1ALOX12
SCHEMBL7321755 0.79 RAB9A (0.41) RAB9ANPC1ALOX5ALDH1A1ALOX12
SCHEMBL8930012 0.79 RAB9A (0.41) RAB9ANPC1ALOX5ALDH1A1ALOX12
SCHEMBL19769133 0.77 FFAR1 (0.42) RAB9ANPC1ALOX5ALDH1A1ALOX12
SCHEMBL10846303 0.76 ALDH1A1 (0.48) RAB9ANPC1ALDH1A1MEN1KMT2A
SCHEMBL6964081 0.74 NPC1 (0.39) RAB9ANPC1ALOX5ALDH1A1ALOX12
SCHEMBL6804005 0.70 KDM4E (0.44) ALDH1A1MEN1KMT2AHPGDRECQL
SCHEMBL9789298 0.68 RAB9A (0.43) RAB9ANPC1ALOX5ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113197331-B Tobacco leaf obtained by fermenting tobacco leaf with medicinal white yeast, fermentation method and application 云南中烟工业有限责任公司 2023-06-13 — — CN disclosed
EP-2865446-B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL KANTO KAGAKU (JP) 2021-09-22 — — EP disclosed
CN-113197331-A Tobacco leaf obtained by fermenting tobacco leaf with medicinal white starter, fermentation method and application 云南中烟工业有限责任公司 2021-08-03 — — CN disclosed
US-10993938-B2 Lactam compound, preparation method and use thereof OCEAN UNIVERSITY OF CHINA (CN) 2021-05-04 — — US disclosed
WO-2020133403-A1 SUBSTITUTED PYRIMIDINE ARYL ESTER DERIVATIVE, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND APPLICATION THEREOF 青岛清原化合物有限公司 2020-07-02 — — WO disclosed
US-20200030312-A1 Lactam Compound, Preparation Method and Use thereof OCEAN UNIVERSITY OF CHINA (CN) 2020-01-30 — — US disclosed
US-20180134700-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-05-17 — — US disclosed
US-9174906-B2 Process for producing optically active secondary alcohol KANTO KAGAKU KABUSHIKI KAISHA (JP) 2015-11-03 — — US disclosed
EP-2621979-B1 BIOCOMPOSITE PANEL ROEMMLER H RESOPAL WERK GMBH (DE) 2015-05-06 — — EP disclosed
EP-2865446-A1 Process for producing optically active secondary alcohol Kanto Kagaku Kabushiki Kaisha (JP) 2015-04-29 — — EP disclosed
EP-1206265-A1 SRC KINASE INHIBITOR COMPOUNDS Merck & Co., Inc. (US) 2002-05-22 — — EP disclosed
US-20020022729-A1 Pyridylfuran and pyridylthiophene compounds KAWAI AKIYOSHI (JP) 2002-02-21 — — US disclosed
EP-0853083-B1 Pyridylfuran and pyridylthiophene compounds and pharmaceutical use thereof PFIZER (US) 2001-09-12 — — EP disclosed
EP-1086941-A1 PROCESS FOR PREPARING REDUCTANTS OF UNSATURATED ORGANIC COMPOUNDS BY THE USE OF TRICHLOROSILANE AND REDUCING AGENTS TOKUYAMA CORPORATION (JP) 2001-03-28 — — EP disclosed
WO-2001000213-A1 SRC KINASE INHIBITOR COMPOUNDS MERCK & CO., INC. (US) 2001-01-04 — — WO disclosed
US-6048880-A THERAPY FOR CYTOKINE SENSITIVE DISEASES PFIZER PHARAMACEUTICALS INC. (JP) 2000-04-11 — — US disclosed
EP-0853083-A1 Pyridylfuran and pyridylthiophene compounds and pharmaceutical use thereof PFIZER INC. (US) 1998-07-15 — — EP disclosed
EP-0521650-B1 Working fluid composition for use in refrigeration system KAO CORP (JP) 1997-08-13 — — EP disclosed
CN-1037509-A Its production process of novel Photoactive compounds and intermediate thereof TRAQSON LTD (GB) 1989-11-29 — — CN disclosed
EP-0334477-A2 Novel photoactive compounds, processes for their production and intermediates therefor MTM RESEARCH CHEMICALS LIMITED (GB) 1989-09-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200030312-A1 Lactam Compound, Preparation Method and Use thereof FURIN, PEPD, PIN1 RAB9A 1387/4885NPC1 810/4885ALOX5 1874/4885
US-10993938-B2 Lactam compound, preparation method and use thereof FURIN, PEPD, PIN1 RAB9A 1387/4885NPC1 810/4885ALOX5 1874/4885
US-20180134700-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 RAB9A 3462/4885NPC1 4595/4885ALOX5 3969/4885
US-20020022729-A1 Pyridylfuran and pyridylthiophene compounds MC2R, CRHR1, NR3C2 RAB9A 4094/4885NPC1 2571/4885ALOX5 224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.