Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966662 | 0.79 | NPSR1 (0.44) | NPC1RAB9ATSHRPDE4DNR3C1 | |
| SCHEMBL6964975 | 0.78 | PLK1 (0.42) | NPC1RAB9ATSHRPDE4DNR3C1 | |
| SCHEMBL6970481 | 0.73 | MEN1 (0.39) | NPC1RAB9ATSHRNR3C1ALDH1A1 | |
| SCHEMBL6965184 | 0.72 | MAPT (0.40) | NPC1NOTUMMAPTUBE2MDCUN1D1 | |
| SCHEMBL6972135 | 0.71 | MEN1 (0.47) | TSHRALDH1A1HSD17B10MAPTLMNA | |
| SCHEMBL6964973 | 0.70 | PLK1 (0.40) | NPC1RAB9ATSHRNR3C1ALDH1A1 | |
| SCHEMBL7335965 | 0.68 | FFAR1 (0.57) | FFAR1FFAR4PLA2G10PLA2G2ALMNA | |
| SCHEMBL20037230 | 0.68 | KLK6 (0.76) | RAB9AKLK6 | |
| SCHEMBL3491515 | 0.67 | FFAR1 (0.72) | FFAR1FFAR4PLA2G10PLA2G2ALMNA | |
| SCHEMBL6364918 | 0.66 | FFAR1 (0.55) | NPC1RAB9AFFAR1FFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |