Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 8/20 | 0.74 |
| ▸ | ACHE | P22303 | 8/20 | 0.74 |
| ▸ | G6PD | P11413 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963146 | 0.86 | BCHE (0.58) | BCHEACHEG6PD | |
| SCHEMBL6954550 | 0.85 | ACHE (1.00) | BCHEACHEG6PDALDH1A1EGFR | |
| SCHEMBL11790970 | 0.83 | BCHE (0.73) | BCHEACHEG6PDALDH1A1MAPT | |
| SCHEMBL16943970 | 0.78 | G6PD (0.68) | BCHEACHEG6PDALDH1A1HTT | |
| SCHEMBL6649884 | 0.77 | G6PD (0.84) | BCHEACHEG6PDALDH1A1SMN1; SMN2 | |
| SCHEMBL22262011 | 0.77 | BCHE (0.57) | BCHEACHEG6PDALDH1A1HTT | |
| SCHEMBL8945368 | 0.76 | G6PD (0.70) | BCHEACHEG6PDALDH1A1MAPT | |
| SCHEMBL8434517 | 0.75 | BCHE (0.72) | BCHEACHEG6PD | |
| SCHEMBL13038170 | 0.75 | ACHE (0.71) | ACHELMNAMAPT | |
| SCHEMBL6803332 | 0.75 | ALDH1A1 (0.55) | BCHEACHEALDH1A1HTTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |