SCHEMBL6965336

SCHEMBL6965336

CCC(OC(C)=O)c1nc(Sc2cccc(Cl)c2)c(C(C)C)[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 1/20 0.39
TP53 P04637 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
HPGD P15428 3/20 0.36
MAPT P10636 3/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
GAA P10253 1/20 0.36
TYMS P04818 3/20 0.35
SLC6A9 P48067 3/20 0.35
ALDH1A1 P00352 3/20 0.34
KDM4E B2RXH2 2/20 0.34
DHFR P00374 1/20 0.34
POLB P06746 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
CSNK2A2 P19784 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6961409 0.90 DHFR (0.30) TYMSDHFR
SCHEMBL7086270 0.88 CA2 (0.36) TYMSSLC6A9ALDH1A1LMNA
SCHEMBL6957342 0.88 CSNK2A2 (0.38) ALOX12TP53RXFP1HPGDMAPT
SCHEMBL6964414 0.88 HPGD (0.38) ALOX12TP53RXFP1HPGDMAPT
SCHEMBL7082599 0.87 ALDH1A1 (0.35) TP53RXFP1HPGDKMT2AGAA
SCHEMBL6974133 0.85 CACNA1C (0.36) HPGDMAPTKMT2AMEN1ALDH1A1
SCHEMBL6960607 0.84 ALOX12 (0.36) ALOX12TP53RXFP1HPGDMAPT
SCHEMBL7081642 0.84 TP53 (0.39) ALOX12TP53RXFP1HPGDMAPT
SCHEMBL7087098 0.82 TP53 (0.39) ALOX12TP53RXFP1HPGDMAPT
SCHEMBL6972114 0.79 LMNA (0.41) ALOX12TP53RXFP1HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed