SCHEMBL6965571

SCHEMBL6965571

O=c1cc[nH]c(=O)n1-c1cccc2ncoc12

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.34
MTNR1A P48039 3/20 0.33
MTNR1B P49286 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8175658 0.74 HTR1A (0.36)
SCHEMBL6969674 0.72 OPRM1 (0.41)
SCHEMBL6970035 0.72 MAPK14 (0.34)
SCHEMBL26684295 0.71 CRBN (0.42) ELANE
SCHEMBL7090787 0.70 CA12 (0.37) ELANEMTNR1AMTNR1B
SCHEMBL9273391 0.68 ADRB1 (0.48)
SCHEMBL7229298 0.67 AHR (0.42)
SCHEMBL8110269 0.67 ADRB1 (0.47)
SCHEMBL15261941 0.67 AURKA (0.33) ELANEMTNR1AMTNR1B
SCHEMBL11378918 0.66 MAPK8 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1131319-B1 3- BENZ(OX/THI)AZOL-7-YL -1H-PYRIMIDINE-2,4-DIONES BASF AG (DE) 2003-09-03 EP claimed
EP-1131319-B1 3- BENZ(OX/THI)AZOL-7-YL -1H-PYRIMIDINE-2,4-DIONES BASF AG (DE) 2003-09-03 EP disclosed