Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.50 |
| ▸ | CCR2 | P41597 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BID | P55957 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6958067 | 0.86 | CCR2 (0.62) | NOD2NOD1CCR2HTR6ALDH1A1 | |
| SCHEMBL6963990 | 0.79 | CCR2 (0.74) | NOD2NOD1CCR2KMT2AMTNR1A | |
| SCHEMBL6966440 | 0.78 | CCR2 (0.45) | NOD2NOD1CCR2PTGER3HTR6 | |
| SCHEMBL9617940 | 0.78 | NOD2 (0.64) | NOD2NOD1CCR2KMT2AHTR6 | |
| SCHEMBL6965196 | 0.77 | NOD2 (0.60) | NOD2NOD1CCR2KMT2AHTR6 | |
| SCHEMBL14627380 | 0.75 | NOD1 (0.78) | NOD2NOD1CCR2ALDH1A1MAPT | |
| SCHEMBL20969368 | 0.74 | NOD2 (0.55) | NOD2NOD1CCR2KMT2AMTNR1A | |
| SCHEMBL10767782 | 0.74 | NOD1 (0.62) | NOD2NOD1CCR2HTR6ALDH1A1 | |
| SCHEMBL16486105 | 0.71 | NOD2 (0.58) | NOD2NOD1CCR2BCL2BID | |
| SCHEMBL18824208 | 0.70 | NOD2 (0.47) | NOD2NOD1CCR2KMT2AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001935-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-10-08 | — | — | EP | disclosed |
| US-6288103-B1 | MONOCYTE CHEMOATTRACTANT PROTEINS ANTAGONIST SUCH AS N-(3-CHLOROPHENYLSULPHONYL)INDOLE-2-CARBOXYLIC ACID; ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 2001-09-11 | — | — | US | disclosed |
| EP-1001935-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999007678-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1999-02-18 | — | — | WO | disclosed |