Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 17/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 17/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063243 | 0.88 | ADRA1D (0.44) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7217049 | 0.80 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BCYP2D6ALDH1A1 | |
| SCHEMBL8138891 | 0.77 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BCYP2D6 | |
| Hydrochloric Acid SCHEMBL8018795 | 0.72 | ADRA1A (0.47) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7141675 | 0.70 | ADRA1A (0.55) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7084988 | 0.70 | ADRA1A (0.49) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7141672 | 0.70 | ADRA1A (0.49) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7747435 | 0.69 | ADRA1D (0.39) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6082708 | 0.69 | MTOR (0.37) | ADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL5660885 | 0.69 | MTOR (0.37) | ADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |