Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 15/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965725 | 0.80 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BALDH1A1CYP2D6 | |
| SCHEMBL7216965 | 0.75 | ADRA1A (0.57) | ADRA1DADRA1AADRA1BHRH1 | |
| SCHEMBL7084868 | 0.75 | ADRA1A (0.57) | ADRA1DADRA1AADRA1BHRH1 | |
| SCHEMBL8063243 | 0.74 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BHRH1 | |
| SCHEMBL13654981 | 0.67 | OPRM1 (0.54) | ALDH1A1CYP2D6CCR1 | |
| SCHEMBL6967188 | 0.66 | OPRM1 (0.50) | ALDH1A1CYP2D6CCR1 | |
| SCHEMBL8138891 | 0.66 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BCYP2D6HRH1 | |
| SCHEMBL23778282 | 0.64 | CYP2D6 (0.53) | ALDH1A1CYP2D6CCR1 | |
| SCHEMBL11121459 | 0.64 | CYP2D6 (0.70) | ALDH1A1CYP2D6CCR1 | |
| SCHEMBL5473543 | 0.64 | KMT2A (0.60) | ALDH1A1CYP2D6CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |