Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | F11 | P03951 | 11/20 | 0.36 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.36 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7747425 | 0.79 | ADRA1A (0.49) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7743435 | 0.75 | CCR2 (0.39) | ADRA1DADRA1AADRA1BAVPR1AF11 | |
| SCHEMBL7743434 | 0.75 | CCR2 (0.39) | ADRA1DADRA1AADRA1BAVPR1AF11 | |
| SCHEMBL7747406 | 0.73 | HRH3 (0.44) | AVPR1AF11CALCRLELOVL6 | |
| SCHEMBL6965725 | 0.69 | ADRA1D (0.44) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7748936 | 0.68 | CCR2 (0.43) | ADRA1DADRA1AADRA1B | |
| SCHEMBL3275750 | 0.65 | CALCRL (0.51) | AVPR1ACALCRL | |
| SCHEMBL10952538 | 0.65 | AVPR1A (0.47) | AVPR1AF11 | |
| SCHEMBL5660885 | 0.65 | MTOR (0.37) | ADRA1DADRA1AADRA1B | |
| SCHEMBL6082708 | 0.65 | MTOR (0.37) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001022919-A2 | SPIRO[BICYCLIC -AZACYCLOALKYL AND -CYCLOALKYL] DERIVATIVES AND USES THEREOF | MERCK & CO., INC. (US) | 2001-04-05 | — | — | WO | disclosed |