Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL614396 | 0.83 | DRD3 (0.52) | DRD3DRD2DRD4OPRM1OPRD1 | |
| SCHEMBL7242386 | 0.82 | OPRM1 (0.51) | DRD3DRD2OPRM1OPRD1OPRK1 | |
| SCHEMBL6643987 | 0.80 | OPRM1 (0.53) | ADRA1AADRA1DADRA1BOPRM1OPRD1 | |
| SCHEMBL905002 | 0.79 | DRD3 (0.57) | DRD3DRD2DRD4ADRA1AADRA1D | |
| SCHEMBL6964398 | 0.79 | ADRA1A (0.52) | DRD3DRD2DRD4ADRA1AADRA1D | |
| SCHEMBL6196008 | 0.77 | ADRA1D (0.62) | ADRA1AADRA1DADRA1BOPRM1OPRD1 | |
| SCHEMBL11465399 | 0.76 | DRD3 (0.44) | DRD3DRD2DRD4ADRA1AADRA1D | |
| SCHEMBL6195779 | 0.76 | SIGMAR1 (0.57) | DRD4ADRA1AOPRM1SIGMAR1 | |
| SCHEMBL6197539 | 0.75 | KCNA3 (0.77) | ADRA1AOPRM1OPRD1OPRK1KCNA3 | |
| SCHEMBL6686824 | 0.75 | SIGMAR1 (0.53) | ADRA1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |