Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 10/20 | 0.57 |
| ▸ | DRD2 | P14416 | 8/20 | 0.57 |
| ▸ | DRD4 | P21917 | 7/20 | 0.57 |
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | HRH1 | P35367 | 6/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.51 |
| ▸ | HTR6 | P50406 | 5/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | DRD5 | P21918 | 4/20 | 0.51 |
| ▸ | HRH2 | P25021 | 4/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904917 | 0.92 | DRD3 (0.52) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL904897 | 0.92 | DRD2 (0.58) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL905011 | 0.91 | DRD2 (0.71) | DRD3DRD2DRD4LMNA | |
| SCHEMBL904932 | 0.91 | DRD3 (0.57) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL904854 | 0.90 | DRD3 (0.50) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL904878 | 0.89 | DRD2 (0.55) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL904925 | 0.88 | OPRM1 (0.52) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL904872 | 0.83 | CYP3A4 (0.55) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL904887 | 0.82 | OPRM1 (0.71) | DRD3DRD2DRD4HTR2AHRH1 | |
| SCHEMBL10423383 | 0.81 | DRD3 (0.50) | DRD3DRD2DRD4HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143444-A2 | DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-11-17 | — | — | WO | disclosed |