Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | C1S | P09871 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697210 | 0.89 | NPC1 (0.42) | NPC1RAB9ANISCHALDH1A1SMN1; SMN2 | |
| SCHEMBL1573195 | 0.83 | NPC1 (0.46) | NPC1RAB9ANISCHSMN1; SMN2KMT2A | |
| SCHEMBL712135 | 0.82 | NPC1 (0.65) | NPC1RAB9ANISCHALDH1A1SMN1; SMN2 | |
| SCHEMBL697617 | 0.81 | NPC1 (0.42) | NPC1RAB9ANISCHALDH1A1SMN1; SMN2 | |
| SCHEMBL706123 | 0.79 | NPC1 (0.37) | NPC1RAB9A | |
| SCHEMBL11137294 | 0.78 | NPC1 (0.42) | NPC1RAB9ANISCHALDH1A1SMN1; SMN2 | |
| SCHEMBL697919 | 0.74 | NPC1 (0.44) | NPC1RAB9ANISCHALDH1A1SMN1; SMN2 | |
| SCHEMBL697433 | 0.74 | NPC1 (0.44) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL703290 | 0.74 | NPC1 (0.44) | NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL697784 | 0.74 | MTOR (0.47) | NPC1RAB9ANISCHALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| EP-1981853-B1 | SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES | PFIZER LTD (GB) | 2011-04-13 | — | — | EP | disclosed |