Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | F2RL1 | P55085 | 10/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698741 | 0.82 | NPC1 (0.63) | NPC1RAB9AF2RL1PIM1KDM4E | |
| SCHEMBL697919 | 0.82 | NPC1 (0.44) | NPC1RAB9AMAOAMAOBKDM4E | |
| SCHEMBL697433 | 0.79 | NPC1 (0.44) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL712135 | 0.78 | NPC1 (0.65) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL705485 | 0.77 | NPC1 (0.38) | NPC1RAB9AF2RL1ALDH1A1 | |
| SCHEMBL1573195 | 0.76 | NPC1 (0.46) | NPC1RAB9A | |
| SCHEMBL697214 | 0.76 | CES2 (0.41) | NPC1RAB9AF2RL1PAK4FGFR1 | |
| SCHEMBL697210 | 0.75 | NPC1 (0.42) | NPC1RAB9AF2RL1ALDH1A1 | |
| SCHEMBL706123 | 0.74 | NPC1 (0.37) | NPC1RAB9AF2RL1 | |
| SCHEMBL696628 | 0.74 | NPC1 (0.47) | NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| CN-101370786-B | Substituted imidazoles and their use as pesticides | PFIZER | 2012-01-11 | — | — | CN | disclosed |