Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696628 | 0.82 | NPC1 (0.47) | NPC1RAB9ANISCHALDH1A1KDM4E | |
| SCHEMBL697784 | 0.81 | MTOR (0.47) | NPC1RAB9ANISCHALDH1A1KDM4E | |
| SCHEMBL1573195 | 0.80 | NPC1 (0.46) | NPC1RAB9ANISCHSMN1; SMN2KMT2A | |
| SCHEMBL6420193 | 0.79 | NPC1 (1.00) | NPC1RAB9ANISCHALDH1A1KDM4E | |
| SCHEMBL703336 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1KDM4ECES2 | |
| SCHEMBL1507800 | 0.78 | CYP19A1 (0.41) | NPC1RAB9AALDH1A1KDM4EPDE4A | |
| SCHEMBL11137294 | 0.78 | NPC1 (0.42) | NPC1RAB9ANISCHALDH1A1KDM4E | |
| SCHEMBL697919 | 0.78 | NPC1 (0.44) | NPC1RAB9ANISCHALDH1A1KDM4E | |
| SCHEMBL697433 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL703290 | 0.78 | NPC1 (0.44) | NPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| EP-1981853-B1 | SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES | PFIZER LTD (GB) | 2011-04-13 | — | — | EP | disclosed |