Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697919 | 0.88 | NPC1 (0.44) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL697587 | 0.86 | KMT2A (0.42) | NPC1RAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL697991 | 0.82 | CYP1A2 (0.41) | NPC1RAB9AKMT2AKDM4ETP53 | |
| SCHEMBL703290 | 0.79 | NPC1 (0.44) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL712135 | 0.78 | NPC1 (0.65) | NPC1RAB9AKMT2AKDM4ETP53 | |
| SCHEMBL27845585 | 0.76 | KMT2A (0.37) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL696226 | 0.76 | KMT2A (0.41) | NPC1RAB9AKMT2AKDM4EMEN1 | |
| SCHEMBL1573195 | 0.76 | NPC1 (0.46) | NPC1RAB9AKMT2AMEN1TDP1 | |
| SCHEMBL696628 | 0.74 | NPC1 (0.47) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL702086 | 0.73 | KMT2A (0.46) | NPC1RAB9AKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| CN-101370786-B | Substituted imidazoles and their use as pesticides | PFIZER | 2012-01-11 | — | — | CN | disclosed |
| EP-1981853-B1 | SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES | PFIZER LTD (GB) | 2011-04-13 | — | — | EP | disclosed |