Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966718 | 0.85 | NPC1 (0.37) | NPC1RAB9AMTNR1AMTNR1BFFAR1 | |
| SCHEMBL6962298 | 0.74 | FFAR1 (0.41) | NPC1RAB9AFFAR1SMN1; SMN2TDP1 | |
| SCHEMBL15282308 | 0.74 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL14031523 | 0.73 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL26066765 | 0.73 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2LMNATDP1 | |
| SCHEMBL6967904 | 0.71 | ACHE (0.42) | NPC1RAB9AMTNR1AMTNR1BFFAR1 | |
| SCHEMBL10144329 | 0.71 | TSHR (0.46) | NPC1RAB9AMTNR1AMTNR1BFFAR1 | |
| SCHEMBL6683261 | 0.71 | HPGD (0.46) | NPC1RAB9AFFAR1SMN1; SMN2LMNA | |
| SCHEMBL24497224 | 0.70 | ALDH1A1 (0.53) | NPC1RAB9AMTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL24497107 | 0.70 | ALDH1A1 (0.38) | MTNR1AMTNR1BFFAR1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |