Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970176 | 0.92 | OPRD1 (0.45) | CHRM2CHRM3OPRD1OPRK1 | |
| SCHEMBL6968136 | 0.91 | OPRD1 (0.44) | CHRM2CHRM3OPRD1OPRK1 | |
| SCHEMBL6965179 | 0.89 | OPRD1 (0.50) | CHRM2CHRM3OPRD1OPRK1 | |
| SCHEMBL6974605 | 0.88 | OPRD1 (0.44) | OPRD1OPRK1ALDH1A1GAA | |
| SCHEMBL7520705 | 0.87 | CHRM2 (0.43) | CHRM2CHRM3OPRD1OPRK1 | |
| SCHEMBL6972934 | 0.86 | PKM (0.45) | OPRD1OPRK1PKMGAA | |
| SCHEMBL6977389 | 0.86 | OPRD1 (0.44) | OPRD1OPRK1PKMGAA | |
| SCHEMBL6965660 | 0.85 | CHRM4 (0.43) | CHRM2CHRM3OPRD1OPRK1 | |
| SCHEMBL6973203 | 0.85 | CYP11B2 (0.42) | CHRM2CHRM3OPRD1OPRK1 | |
| SCHEMBL6969698 | 0.85 | ALDH1A1 (0.51) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |