Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209083 | 0.92 | PDE4B (0.38) | PTGS1PTGS2HTR6SLC6A3SLC6A2 | |
| SCHEMBL8209788 | 0.88 | ALDH1A1 (0.38) | PTGS1PTGS2MAOBSLC6A3SLC6A2 | |
| SCHEMBL8201991 | 0.88 | HIF1A (0.41) | PTGS1PTGS2ALDH1A1 | |
| SCHEMBL8211654 | 0.87 | PTGS1 (0.35) | PTGS1PTGS2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8209787 | 0.83 | SLC6A2 (0.40) | PTGS2HTR6SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL6968879 | 0.83 | DYRK1A (0.42) | HTR6SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL8208589 | 0.83 | KMT2A (0.44) | PTGS2HTR6SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8201465 | 0.81 | HTR6 (0.43) | HTR6 | |
| SCHEMBL8208559 | 0.80 | KMT2A (0.51) | HTR6ACHEALDH1A1 | |
| SCHEMBL8201598 | 0.79 | AKR1C3 (0.46) | PTGS1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | claimed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | claimed |
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |