Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208574 | 0.90 | AKR1C3 (0.42) | SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL8201598 | 0.89 | AKR1C3 (0.46) | KMT2A | |
| SCHEMBL6968879 | 0.88 | DYRK1A (0.42) | SLC6A2SLC6A4SLC6A3KMT2AHTR6 | |
| SCHEMBL8208589 | 0.88 | KMT2A (0.44) | SLC6A2SLC6A4SLC6A3KMT2APTGS2 | |
| SCHEMBL8213329 | 0.83 | PTGS1 (0.38) | SLC6A2SLC6A4SLC6A3PTGS2HTR6 | |
| SCHEMBL8200926 | 0.80 | KMT2A (0.47) | KMT2APTGS2POLBMEN1HTR6 | |
| SCHEMBL8208559 | 0.78 | KMT2A (0.51) | KMT2APOLBCYP2D6CYP2C19MEN1 | |
| SCHEMBL8209521 | 0.78 | HTR6 (0.51) | HTR6 | |
| SCHEMBL8209083 | 0.75 | PDE4B (0.38) | SLC6A2SLC6A4SLC6A3KMT2APTGS2 | |
| SCHEMBL8209788 | 0.75 | ALDH1A1 (0.38) | SLC6A2SLC6A4SLC6A3KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | claimed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | claimed |
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |