Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 11/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208574 | 0.89 | AKR1C3 (0.42) | AKR1C3AKR1C2KMT2AMGLL | |
| SCHEMBL8209787 | 0.89 | SLC6A2 (0.40) | KMT2A | |
| SCHEMBL8208559 | 0.87 | KMT2A (0.51) | KMT2AACHE | |
| SCHEMBL8209083 | 0.87 | PDE4B (0.38) | AKR1C3AKR1C2PTGS1AKR1C4KMT2A | |
| SCHEMBL8201582 | 0.80 | HTR6 (0.50) | — | |
| SCHEMBL8213329 | 0.79 | PTGS1 (0.38) | PTGS1ACHE | |
| SCHEMBL6968879 | 0.77 | DYRK1A (0.42) | KMT2A | |
| SCHEMBL8208589 | 0.76 | KMT2A (0.44) | KMT2A | |
| SCHEMBL8200926 | 0.75 | KMT2A (0.47) | KMT2AACHE | |
| SCHEMBL8211654 | 0.75 | PTGS1 (0.35) | PTGS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | claimed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | claimed |
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |