Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973095 | 0.85 | HRH4 (0.56) | HRH4ALDH1A1KMT2ANPSR1HRH3 | |
| SCHEMBL6968638 | 0.81 | KMT2A (0.57) | HRH4ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30366498 | 0.80 | ALDH1A1 (0.65) | ALDH1A1CYP2D6ATMNPSR1SMN1; SMN2 | |
| SCHEMBL6972466 | 0.77 | ALDH1A1 (0.44) | ALDH1A1CYP2D6ATMKMT2ANPSR1 | |
| SCHEMBL6976878 | 0.76 | HSD11B1 (0.51) | ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL5762663 | 0.75 | MEN1 (0.63) | ALDH1A1MEN1KMT2ASMN1; SMN2PLAT | |
| SCHEMBL6976438 | 0.74 | NPC1 (0.45) | KMT2A | |
| SCHEMBL6981137 | 0.74 | SMN1; SMN2 (0.54) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5765418 | 0.73 | PLAT (0.46) | ALDH1A1MEN1KMT2ASMN1; SMN2PLAT | |
| SCHEMBL6981142 | 0.73 | GLA (0.55) | MEN1KMT2ANPSR1HRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |