Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976878 | 0.85 | HSD11B1 (0.51) | ALDH1A1LMNARAB9AKMT2AHPGD | |
| SCHEMBL6976781 | 0.84 | ALDH1A1 (0.43) | ALDH1A1LMNARAB9AP2RX3NPSR1 | |
| SCHEMBL6981137 | 0.83 | SMN1; SMN2 (0.54) | ALDH1A1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL6981142 | 0.82 | GLA (0.55) | NPSR1TSHRKMT2APKMMAPT | |
| SCHEMBL6976438 | 0.81 | NPC1 (0.45) | LMNARAB9AKMT2AGAATRPC6 | |
| SCHEMBL6977211 | 0.79 | MMP1 (0.44) | — | |
| SCHEMBL7123772 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1RAB9ATSHRKMT2ASMN1; SMN2 | |
| SCHEMBL6972446 | 0.78 | HSD17B10 (0.48) | ALDH1A1LMNARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6968922 | 0.77 | HRH4 (0.51) | ALDH1A1NPSR1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL30366498 | 0.71 | ALDH1A1 (0.65) | ALDH1A1LMNANPSR1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |