Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 5/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | AXL | P30530 | 3/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981142 | 0.88 | GLA (0.55) | MEN1KMT2API4KBGLAMAPT | |
| SCHEMBL6976878 | 0.86 | HSD11B1 (0.51) | MEN1KMT2ACDK1IGF1RFGFR1 | |
| SCHEMBL6972466 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2KMT2AALDH1A1MAPTGAA | |
| SCHEMBL6976438 | 0.78 | NPC1 (0.45) | KMT2AGAA | |
| SCHEMBL6972446 | 0.78 | HSD17B10 (0.48) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL6976781 | 0.76 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7123772 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6973351 | 0.74 | DRD2 (0.52) | MEN1KMT2ACDK1IGF1RFGFR1 | |
| SCHEMBL6968922 | 0.74 | HRH4 (0.51) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6974760 | 0.71 | MAP3K12 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |