Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014640 | 0.78 | OR51E2 (0.37) | OR51E2FKBP5CRBN | |
| SCHEMBL2482364 | 0.76 | CHRNA7 (0.38) | NOS3NOS1NOS2OR51E2FKBP5 | |
| SCHEMBL2482486 | 0.73 | CYP1A2 (0.47) | NOS1NOS2OR51E2FKBP5CRBN | |
| SCHEMBL27924745 | 0.73 | OR51E2 (0.33) | OR51E2FKBP5CRBN | |
| SCHEMBL28731850 | 0.73 | SIGMAR1 (0.40) | OR51E2FKBP5CRBN | |
| SCHEMBL8201975 | 0.72 | — | — | |
| SCHEMBL11527036 | 0.72 | NOS3 (0.50) | NOS3NOS1NOS2 | |
| SCHEMBL2526110 | 0.72 | HTT (0.41) | NOS3NOS1NOS2OR51E2FKBP5 | |
| SCHEMBL9766490 | 0.71 | CYP1A2 (0.49) | — | |
| SCHEMBL3962160 | 0.70 | NOS3 (0.49) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| CN-1105706-C | Cyclic amidino formulations useful as nitric oxide synthase inhibitors | SEARLE & CO (US) | 2003-04-16 | — | — | CN | disclosed |
| CN-1305993-A | Cyclic guanyl preparation used as nitrogen oxide synthetic enzyme inhibitor | SEARLE & CO (US) | 2001-08-01 | — | — | CN | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| CN-1189823-A | Cyclic amidino formulations useful as nitric oxide synthase inhibitors | SEARLE & CO (US) | 1998-08-05 | — | — | CN | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |