Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6980562 | 0.99 | ALDH1A1 (0.39) | ALDH1A1CCR3C5AR1DRD4SIGMAR1 | |
| SCHEMBL6972327 | 0.89 | SIGMAR1 (0.49) | ALDH1A1C5AR1SIGMAR1IP6K1POLB | |
| Hydrochloric Acid SCHEMBL6972316 | 0.88 | SIGMAR1 (0.48) | ALDH1A1C5AR1SIGMAR1IP6K1POLB | |
| SCHEMBL6977878 | 0.85 | KDM4E (0.40) | ALDH1A1C5AR1DRD4DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL6969218 | 0.84 | KDM4E (0.39) | ALDH1A1C5AR1DRD4SIGMAR1DRD2 | |
| SCHEMBL6976116 | 0.83 | CCR3 (0.46) | ALDH1A1CCR3DRD4SIGMAR1DRD2 | |
| SCHEMBL6965169 | 0.83 | MGLL (0.45) | PTGER1 | |
| Hydrochloric Acid SCHEMBL6971416 | 0.82 | CCR3 (0.45) | ALDH1A1CCR3DRD4SIGMAR1DRD2 | |
| SCHEMBL6976701 | 0.82 | PTGER1 (0.42) | C5AR1JAK2JAK1PTGER1IP6K1 | |
| SCHEMBL6969059 | 0.82 | SIGMAR1 (0.51) | ALDH1A1CCR3DRD4SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |