Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6972316 | 0.99 | SIGMAR1 (0.48) | SIGMAR1C5AR1CXCR3IP6K1BCHE | |
| SCHEMBL6969273 | 0.89 | ALDH1A1 (0.39) | SIGMAR1C5AR1CXCR3IP6K1KDM4E | |
| Hydrochloric Acid SCHEMBL6980562 | 0.89 | ALDH1A1 (0.39) | SIGMAR1C5AR1CXCR3IP6K1KDM4E | |
| SCHEMBL6977878 | 0.87 | KDM4E (0.40) | C5AR1KDM4EMAPTALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL6969218 | 0.86 | KDM4E (0.39) | SIGMAR1C5AR1KDM4EMAPTALDH1A1 | |
| SCHEMBL6976116 | 0.85 | CCR3 (0.46) | SIGMAR1CXCR3ALDH1A1POLBMEN1 | |
| Hydrochloric Acid SCHEMBL6971416 | 0.84 | CCR3 (0.45) | SIGMAR1CXCR3ALDH1A1POLBMEN1 | |
| SCHEMBL6969059 | 0.83 | SIGMAR1 (0.51) | SIGMAR1KDM4EMAPTALDH1A1POLB | |
| SCHEMBL6965169 | 0.83 | MGLL (0.45) | — | |
| SCHEMBL6976284 | 0.82 | OPRL1 (0.48) | SIGMAR1ALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |