Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CPS1 | P31327 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.56 |
| ▸ | MGLL | Q99685 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.53 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6969837 | 0.99 | POLB (0.59) | POLBALDH1A1ACHEBACE1GAA | |
| SCHEMBL6973342 | 0.82 | MGLL (0.67) | HSD11B1MGLL | |
| SCHEMBL6210853 | 0.82 | POLB (0.89) | POLBALDH1A1ACHEBACE1GAA | |
| SCHEMBL1720550 | 0.82 | POLB (0.89) | POLBALDH1A1ACHEBACE1GAA | |
| SCHEMBL6969906 | 0.81 | MGLL (0.64) | ACHEHSD11B1MGLLSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6979800 | 0.80 | MGLL (0.63) | ACHEHSD11B1MGLLSMN1; SMN2 | |
| SCHEMBL1340897 | 0.79 | NOS2 (0.48) | POLBALDH1A1CPS1LMNASMN1; SMN2 | |
| SCHEMBL2533157 | 0.74 | ALDH1A1 (0.67) | POLBALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL31366495 | 0.74 | ALDH1A1 (0.67) | POLBALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL1720183 | 0.74 | MGLL (0.82) | POLBALDH1A1ACHEHSD11B1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |