Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.64 |
| ▸ | CPB1 | P15086 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6979800 | 0.99 | MGLL (0.63) | MGLLHSD11B1CPB1KMT2AMEN1 | |
| SCHEMBL6973342 | 0.84 | MGLL (0.67) | MGLLHSD11B1KMT2AMEN1 | |
| SCHEMBL1720183 | 0.83 | MGLL (0.82) | MGLLHSD11B1CPB1KMT2AMEN1 | |
| SCHEMBL6969303 | 0.81 | POLB (0.60) | MGLLHSD11B1ACHESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6969837 | 0.81 | POLB (0.59) | MGLLHSD11B1ACHESMN1; SMN2 | |
| SCHEMBL6575271 | 0.79 | HSD11B1 (0.50) | MGLLHSD11B1 | |
| SCHEMBL4148296 | 0.79 | HSD11B1 (0.52) | MGLLHSD11B1CPB1 | |
| SCHEMBL6348741 | 0.79 | HSD11B1 (1.00) | MGLLHSD11B1KMT2A | |
| SCHEMBL9029952 | 0.79 | SMN1; SMN2 (0.82) | MGLLHSD11B1KMT2AMEN1ACHE | |
| SCHEMBL1673861 | 0.78 | MAPT (0.73) | MGLLHSD11B1KMT2AMEN1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |