Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974453 | 0.91 | ENPP2 (0.38) | LMNAPTGDR2RXFP1ENPP2HDAC1 | |
| SCHEMBL8343030 | 0.91 | LMNA (0.40) | LMNAPTGDR2RXFP1ENPP2SLC22A12 | |
| SCHEMBL8344784 | 0.91 | LMNA (0.38) | LMNAPTGDR2RXFP1ENPP2ALDH1A1 | |
| SCHEMBL7084157 | 0.89 | TLR7 (0.37) | LMNAPTGDR2ENPP2TLR7ALDH1A1 | |
| SCHEMBL8346904 | 0.88 | CFTR (0.41) | LMNAALDH1A1CYP1A2SMN1; SMN2MAPT | |
| SCHEMBL8346908 | 0.88 | CFTR (0.41) | LMNAALDH1A1CYP1A2SMN1; SMN2MAPT | |
| SCHEMBL7084830 | 0.87 | TLR7 (0.40) | PTGDR2ENPP2TLR7ALDH1A1HDAC1 | |
| SCHEMBL6973209 | 0.86 | HRH1 (0.40) | LMNAPTGDR2TLR7ALDH1A1HDAC1 | |
| SCHEMBL6966916 | 0.86 | CYP1A2 (0.35) | PTGDR2ENPP2TLR7ALDH1A1HDAC1 | |
| SCHEMBL6963974 | 0.86 | ALDH1A1 (0.37) | LMNAPTGDR2TLR7ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |