SCHEMBL7084830

SCHEMBL7084830

CC(C)c1nc(CCCO)n(Cc2ccccn2)c1Sc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 1/20 0.40
HRH1 P35367 1/20 0.35
ALDH1A1 P00352 5/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALOX5AP P20292 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
HDAC1 Q13547 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
PKM P14618 1/20 0.32
TSHR P16473 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
TP53 P04637 1/20 0.31
ENPP2 Q13822 1/20 0.31
KCNH2 Q12809 1/20 0.31
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7084157 0.94 TLR7 (0.37) TLR7HRH1ALDH1A1ALOX5APPTGDR2
SCHEMBL6974738 0.90 TLR7 (0.36) TLR7HRH1ALDH1A1KMT2AALOX5AP
SCHEMBL6974023 0.90 TLR8 (0.36) TLR7HRH1ALDH1A1MEN1KMT2A
SCHEMBL6974995 0.90 GRIN1 (0.36) TLR7HRH1ALDH1A1KMT2ATSHR
SCHEMBL6970195 0.89 TLR7 (0.35) TLR7HRH1ALDH1A1MEN1KMT2A
SCHEMBL6973869 0.89 TLR7 (0.35) TLR7HRH1ALDH1A1ALOX5APTDP1
SCHEMBL6963974 0.89 ALDH1A1 (0.37) TLR7HRH1ALDH1A1ALOX5APPTGDR2
SCHEMBL6973209 0.87 HRH1 (0.40) TLR7HRH1ALDH1A1ALOX5APPTGDR2
SCHEMBL6969389 0.87 LMNA (0.42) TLR7ALDH1A1ALOX5APPTGDR2CYP1A2
SCHEMBL6967115 0.86 CFTR (0.42) ALDH1A1MEN1KMT2ACYP1A2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed