SCHEMBL6969487

SCHEMBL6969487

[O]C(=O)NC(=O)C(Cl)(Cl)Cl

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
TP53 P04637 1/20 0.37
TSHR P16473 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL712181 0.83 ALDH1A1 (0.44) ALDH1A1TP53TSHRL3MBTL1MEN1
SCHEMBL31734135 0.78 ALDH1A1 (0.39) ALDH1A1TP53TSHRL3MBTL1MEN1
SCHEMBL3136565 0.75 ALDH1A1 (0.44) ALDH1A1TP53TSHRL3MBTL1MEN1
SCHEMBL1563693 0.73 CRBN (0.41) ALDH1A1TP53TSHRL3MBTL1MEN1
SCHEMBL13436162 0.73 CRBN (0.41) ALDH1A1TP53TSHRL3MBTL1MEN1
SCHEMBL6234856 0.69 L3MBTL1 (0.32) ALDH1A1TP53TSHRL3MBTL1
SCHEMBL6959890 0.69 L3MBTL1 (0.32) ALDH1A1TP53TSHRL3MBTL1
SCHEMBL11318749 0.69 ALDH1A1 (0.32) ALDH1A1TP53TSHRL3MBTL1MEN1
SCHEMBL4119686 0.69 L3MBTL1 (0.46) ALDH1A1TP53TSHRL3MBTL1MAPT
SCHEMBL6959896 0.69 L3MBTL1 (0.37) ALDH1A1TP53TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed
US-5183929-A Method for production of T-butyl 3-oxobutyrates and their use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-02-02 US disclosed
US-5109131-A METHOD FOR PRODUCTION OF T-BUTYL 3-OXOBUTYRATES AND THEIR USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-04-28 US disclosed
US-4965260-A PENICILLINS CIBA-GEIGY CORPORATION (US) 1990-10-23 US disclosed
EP-0324418-A2 Method for production of t-butyl- 3-oxobutyrates and their use Takeda Chemical Industries, Ltd. (JP) 1989-07-19 EP disclosed
US-4680390-A CEPHALOSPORINS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-07-14 US disclosed
US-4520194-A BACTERICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-05-28 US disclosed
US-4510138-A 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1985-04-09 US disclosed
US-4278671-A ANTIBIOTICS, BACTERICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1981-07-14 US disclosed