Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL712181 | 0.83 | ALDH1A1 (0.44) | ALDH1A1TP53TSHRL3MBTL1HPGD | |
| SCHEMBL31734135 | 0.78 | ALDH1A1 (0.39) | ALDH1A1TP53TSHRL3MBTL1HPGD | |
| SCHEMBL14747258 | 0.77 | ALDH1A1 (0.33) | ALDH1A1TP53TSHR | |
| SCHEMBL6969487 | 0.75 | ALDH1A1 (0.37) | ALDH1A1TP53TSHRL3MBTL1HPGD | |
| SCHEMBL1563693 | 0.73 | CRBN (0.41) | ALDH1A1TP53TSHRL3MBTL1HPGD | |
| SCHEMBL13436162 | 0.73 | CRBN (0.41) | ALDH1A1TP53TSHRL3MBTL1HPGD | |
| SCHEMBL6234856 | 0.69 | L3MBTL1 (0.32) | ALDH1A1TP53TSHRL3MBTL1 | |
| SCHEMBL4119686 | 0.69 | L3MBTL1 (0.46) | ALDH1A1TP53TSHRL3MBTL1HPGD | |
| SCHEMBL11318749 | 0.69 | ALDH1A1 (0.32) | ALDH1A1TP53TSHRL3MBTL1HPGD | |
| SCHEMBL6959890 | 0.69 | L3MBTL1 (0.32) | ALDH1A1TP53TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240199612-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES (US) | 2024-06-20 | — | — | US | disclosed |
| US-20240182603-A1 | SULFUR-SUBSTITUTED SUGAR TO STABILIZE OLIGOSACCHARIDE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-06-06 | — | — | US | disclosed |
| EP-4308227-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| US-20230114498-A1 | COMPOSITION AND METHOD FOR TREATING DERMATOLOGICAL DISORDERS USING RETINAMIDES | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2023-04-13 | — | — | US | disclosed |
| WO-2022228568-A1 | PYRIDINO- OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 劲方医药科技(上海)有限公司 | 2022-11-03 | — | — | WO | disclosed |
| WO-2022197755-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| CN-115087487-A | Compositions and methods for treating skin disorders using tretinoin | 马里兰大学巴尔的摩分校 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127438-A1 | COMPOSITION AND METHOD FOR TREATING DERMATOLOGICAL DISORDERS USING RETINAMIDES | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3114126-B1 | 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-10-31 | — | — | EP | disclosed |
| US-10106544-B2 | 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-10-23 | — | — | US | disclosed |
| US-5183929-A | Method for production of T-butyl 3-oxobutyrates and their use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-02-02 | — | — | US | disclosed |
| US-5109131-A | METHOD FOR PRODUCTION OF T-BUTYL 3-OXOBUTYRATES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-28 | — | — | US | disclosed |
| US-4965260-A | PENICILLINS | CIBA-GEIGY CORPORATION (US) | 1990-10-23 | — | — | US | disclosed |
| EP-0324418-A2 | Method for production of t-butyl- 3-oxobutyrates and their use | Takeda Chemical Industries, Ltd. (JP) | 1989-07-19 | — | — | EP | disclosed |
| US-4826820-A | BACTERICIDES | BEECHAM GROUP P.L.C. (GB) | 1989-05-02 | — | — | US | disclosed |
| US-4680390-A | CEPHALOSPORINS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-07-14 | — | — | US | disclosed |
| EP-0216169-A2 | Erythromycin derivatives | BEECHAM GROUP PLC (GB) | 1987-04-01 | — | — | EP | disclosed |
| US-4520194-A | BACTERICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-05-28 | — | — | US | disclosed |
| US-4510138-A | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-04-09 | — | — | US | disclosed |
| US-4278671-A | ANTIBIOTICS, BACTERICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230114498-A1 | COMPOSITION AND METHOD FOR TREATING DERMATOLOGICAL DISORDERS USING RETINAMIDES | NR2E3, RPS6KA2, NEK1 | ALDH1A1 3500/4885TP53 3647/4885TSHR 2591/4885 |
| US-20240182603-A1 | SULFUR-SUBSTITUTED SUGAR TO STABILIZE OLIGOSACCHARIDE | TST, CD44, CSGALNACT1 | ALDH1A1 3579/4885TP53 626/4885TSHR 989/4885 |
| US-10106544-B2 | 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents | CCNI, H1-0, H1-3 | ALDH1A1 796/4885TP53 3092/4885TSHR 2525/4885 |
| US-20240199612-A1 | IMIDAZOPYRIDINYL INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK1, KLK4 | ALDH1A1 2752/4885TP53 4316/4885TSHR 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.