Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974363 | 0.86 | HTR1A (0.41) | OPRD1OPRK1SPHK2VNN1POLB | |
| SCHEMBL6970176 | 0.85 | OPRD1 (0.45) | OPRD1OPRK1 | |
| SCHEMBL6968136 | 0.84 | OPRD1 (0.44) | OPRD1OPRK1 | |
| SCHEMBL6980054 | 0.84 | OPRD1 (0.40) | OPRD1OPRK1CNR1CNR2 | |
| SCHEMBL6972306 | 0.83 | CYP2D6 (0.39) | OPRD1OPRK1VNN1 | |
| SCHEMBL6965660 | 0.83 | CHRM4 (0.43) | OPRD1OPRK1 | |
| SCHEMBL6972934 | 0.82 | PKM (0.45) | OPRD1OPRK1 | |
| SCHEMBL6977389 | 0.81 | OPRD1 (0.44) | OPRD1OPRK1 | |
| SCHEMBL6973203 | 0.81 | CYP11B2 (0.42) | OPRD1OPRK1 | |
| SCHEMBL6965179 | 0.79 | OPRD1 (0.50) | OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |