Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970176 | 0.88 | OPRD1 (0.45) | OPRD1HSD11B1OPRK1CCR3 | |
| SCHEMBL6968136 | 0.87 | OPRD1 (0.44) | OPRD1HSD11B1OPRK1CCR3 | |
| SCHEMBL6973203 | 0.87 | CYP11B2 (0.42) | CHRM4OPRD1OPRK1CCR3 | |
| SCHEMBL6965660 | 0.85 | CHRM4 (0.43) | CHRM4OPRD1OPRK1 | |
| SCHEMBL6976119 | 0.85 | ALDH1A1 (0.50) | L3MBTL1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6969717 | 0.83 | OPRD1 (0.39) | OPRD1OPRK1VNN1 | |
| SCHEMBL6965179 | 0.82 | OPRD1 (0.50) | CYP2D6OPRD1OPRK1 | |
| SCHEMBL6967499 | 0.82 | CHRM2 (0.45) | OPRD1OPRK1ALDH1A1GAAMAPT | |
| SCHEMBL6974363 | 0.82 | HTR1A (0.41) | OPRD1HSD11B1OPRK1VNN1CCR3 | |
| SCHEMBL6972934 | 0.81 | PKM (0.45) | OPRD1OPRK1CCR3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |