Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963693 | 0.83 | MAPT (0.60) | LMNATDP1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6961993 | 0.78 | MAPT (0.43) | LMNATDP1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6973656 | 0.78 | PDE7A (0.60) | LMNATDP1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3506729 | 0.74 | KDM4E (0.77) | LMNATDP1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6968741 | 0.74 | KDM4E (0.57) | LMNAKMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6962478 | 0.74 | AGTR1 (0.53) | LMNAKMT2AKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL25199024 | 0.73 | LMNA (1.00) | LMNATDP1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6973592 | 0.73 | LMNA (0.44) | LMNATDP1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6970234 | 0.73 | MAPT (0.46) | LMNATDP1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6966448 | 0.72 | LMNA (0.53) | LMNAKMT2AKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |