Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27581731 | 0.85 | PDE7A (0.67) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL6963693 | 0.81 | MAPT (0.60) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL6965142 | 0.81 | PDE7A (0.47) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL6968494 | 0.79 | ALDH1A1 (0.64) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL4029471 | 0.78 | MEN1 (0.76) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL6969782 | 0.78 | LMNA (0.57) | PDE7ALMNAKMT2AMAPTMEN1 | |
| SCHEMBL27581742 | 0.77 | PDE7A (0.75) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL6968103 | 0.77 | MAPT (0.48) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL6973592 | 0.76 | LMNA (0.44) | PDE7ALMNAKMT2AMAPTMEN1 | |
| SCHEMBL8357964 | 0.76 | SLC6A2 (0.49) | PDE7APDE4BPDE4DPDE7BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |