Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971991 | 0.80 | TP53 (0.36) | TP53HPGDTDP1L3MBTL1TSHR | |
| SCHEMBL6965560 | 0.68 | — | — | |
| SCHEMBL2223238 | 0.63 | TP53 (0.54) | TP53TDP1L3MBTL1TSHRPOLB | |
| SCHEMBL15782799 | 0.63 | TP53 (0.39) | TP53HPGDTDP1L3MBTL1TSHR | |
| SCHEMBL8635719 | 0.62 | ALDH1A1 (0.53) | TP53ESR1HPGDTSHRHSD17B10 | |
| SCHEMBL7068796 | 0.62 | TP53 (0.38) | TP53ESR1TDP1L3MBTL1TSHR | |
| SCHEMBL4837753 | 0.60 | RIPK1 (0.33) | ESR1 | |
| SCHEMBL15855878 | 0.60 | L3MBTL1 (0.53) | TP53TDP1L3MBTL1TSHRPOLB | |
| SCHEMBL1436063 | 0.60 | ALDH1A1 (0.51) | TP53ESR1HPGDTSHRHSD17B10 | |
| SCHEMBL6977127 | 0.60 | ALDH1A1 (0.51) | TP53ESR1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |