Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084297 | 0.93 | LMNA (0.40) | ALDH1A1HTTSMN1; SMN2POLBTHRB | |
| SCHEMBL7081725 | 0.90 | TP53 (0.32) | HTTTLR7POLBTHRBIDO1 | |
| SCHEMBL7085972 | 0.90 | GRIN1 (0.37) | ALDH1A1HTTSMN1; SMN2TLR7POLB | |
| SCHEMBL7087408 | 0.89 | POLB (0.38) | ALDH1A1HTTSMN1; SMN2TLR7POLB | |
| SCHEMBL7086713 | 0.88 | KMT2A (0.35) | ALDH1A1MEN1KMT2AGABRA5GABRA1 | |
| SCHEMBL6972982 | 0.87 | MEN1 (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2ANAMPT | |
| SCHEMBL7080158 | 0.86 | GRIN1 (0.38) | ALDH1A1HTTSMN1; SMN2IDO1NAMPT | |
| SCHEMBL6972772 | 0.86 | RECQL (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ANAMPT | |
| SCHEMBL6973652 | 0.84 | SRC (0.37) | ALDH1A1TLR7MEN1KMT2AGABRA5 | |
| SCHEMBL6957238 | 0.84 | GABRA5 (0.36) | ALDH1A1TLR7KMT2AGABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |