Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 9/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085972 | 0.93 | GRIN1 (0.37) | GRIN1GRIN2BNAMPTGNRHRALDH1A1 | |
| SCHEMBL6967611 | 0.91 | GRIN1 (0.35) | GRIN1GRIN2BNAMPTGNRHRALDH1A1 | |
| SCHEMBL7084297 | 0.90 | LMNA (0.40) | GRIN1GRIN2BNAMPTALDH1A1HTT | |
| SCHEMBL7087408 | 0.89 | POLB (0.38) | NAMPTGNRHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6961326 | 0.89 | GRIN1 (0.39) | GRIN1GRIN2BALDH1A1LMNAS1PR3 | |
| SCHEMBL7086202 | 0.87 | LMNA (0.41) | GRIN1GRIN2BNAMPTALDH1A1LMNA | |
| SCHEMBL6964743 | 0.87 | MAPT (0.41) | GNRHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6973170 | 0.86 | RECQL (0.43) | GRIN1GRIN2BNAMPTALDH1A1LMNA | |
| SCHEMBL6970692 | 0.86 | ALDH1A1 (0.36) | GRIN1GRIN2BNAMPTALDH1A1HTT | |
| SCHEMBL7083464 | 0.85 | GRIN1 (0.39) | GRIN1GRIN2BALDH1A1LMNAIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |