Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15856898 | 0.80 | CRHR1 (0.45) | CRHR1CYP1A2CYP2A6PSMB5KMT2A | |
| SCHEMBL6971750 | 0.80 | CRHR1 (0.45) | CRHR1CYP1A2CYP2A6PSMB5MAPT | |
| SCHEMBL7260889 | 0.78 | PLAU (0.50) | CYP1A2PLAUMAPTKMT2AALDH1A1 | |
| SCHEMBL11976492 | 0.76 | ALDH1A1 (0.47) | PLAUMAPTL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6975785 | 0.74 | MAPT (0.44) | CRHR1CYP1A2MAPTL3MBTL1KMT2A | |
| SCHEMBL6974732 | 0.72 | CRHR1 (0.50) | CRHR1MAPTHTT | |
| SCHEMBL6972554 | 0.72 | CRHR1 (0.80) | CRHR1 | |
| SCHEMBL10782921 | 0.71 | ADORA2A (0.47) | PLAUMAPTALDH1A1HPGDHTT | |
| SCHEMBL30020105 | 0.70 | PLAU (0.47) | CYP1A2CYP2A6PLAUMAPTKMT2A | |
| SCHEMBL2345378 | 0.70 | PLAU (0.47) | CYP1A2CYP2A6PLAUMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946520-B1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6440969-B2 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-08-27 | — | — | US | disclosed |
| US-6353103-B1 | STRESS RELATED DISORDERS SUCH AS POST TRAUMATIC STRESS DISORDER (PTSD) AS WELL AS DEPRESSION, HEADACHE AND ANXIETY. | NEUROGEN CORPORATION | 2002-03-05 | — | — | US | disclosed |
| US-20010036945-A1 | Certain Isoquinolinamine and phthalazinamine derivatives; corticotropin-releasing factor receptor CRF1 specific ligands | NEUROGEN CORPORATION. | 2001-11-01 | — | — | US | disclosed |
| US-6235752-B1 | CORTICOTROPIN RELEASING FACTOR; PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2001-05-22 | — | — | US | disclosed |
| US-6114530-A | ISOQUIOLINAMINES AND PHTHALAZINAMINES USEFUL IN TREATING STRESS RELATED DISORDERES SUCH AS POST TRAUMATIC STRESS DISORDER AS WELL AS DEPRESSION, HEADACHE AND ANXIETY | NEUROGEN CORPORATION (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0946520-A1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORPORATION (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027066-A1 | ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS | NEUROGEN CORPORATION (US) | 1998-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010036945-A1 | Certain Isoquinolinamine and phthalazinamine derivatives; corticotropin-releasing factor receptor CRF1 specific ligands | CRHR1, CRH, CRHR2 | CRHR1 1/4885CYP1A2 3008/4885CYP2A6 3148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.