Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6981953 | 0.99 | CCR3 (0.42) | CCR3SIGMAR1BRS3HSD11B1KDM4E | |
| SCHEMBL11743900 | 0.79 | SIGMAR1 (0.66) | CCR3SIGMAR1KDM4ECXCR3OPRL1 | |
| SCHEMBL6975022 | 0.78 | MMP2 (0.51) | BRS3CHRM2 | |
| SCHEMBL6969631 | 0.75 | HSD11B1 (0.44) | CCR3SIGMAR1HSD11B1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL6972117 | 0.74 | HSD11B1 (0.44) | CCR3SIGMAR1HSD11B1MAPTOPRL1 | |
| SCHEMBL6966719 | 0.74 | CCR3 (0.45) | CCR3SIGMAR1HSD11B1KDM4EMAPT | |
| SCHEMBL6969018 | 0.71 | CCR3 (0.45) | CCR3SIGMAR1MAPTCXCR3OPRL1 | |
| SCHEMBL6969667 | 0.71 | CCR3 (0.43) | CCR3SIGMAR1HSD11B1CXCR3OPRL1 | |
| SCHEMBL6975096 | 0.71 | ALDH1A1 (0.53) | MAPTMEN1ALDH1A1TSHRKMT2A | |
| Hydrochloric Acid SCHEMBL6979143 | 0.70 | CCR3 (0.44) | CCR3SIGMAR1MAPTCXCR3OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |