Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974432 | 0.92 | EPHX1 (0.35) | EPHX1SLC6A9MAPTALDH1A1LMNA | |
| SCHEMBL7087212 | 0.84 | EPHX1 (0.33) | EPHX1SLC6A9MAPTALDH1A1LMNA | |
| SCHEMBL6974491 | 0.83 | MEN1 (0.37) | EPHX1SLC6A9MAPTALDH1A1LMNA | |
| SCHEMBL6973633 | 0.83 | EPHX1 (0.34) | EPHX1SLC6A9MAPTALDH1A1LMNA | |
| SCHEMBL6965378 | 0.82 | LMNA (0.32) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL6973034 | 0.81 | MAPT (0.36) | EPHX1SLC6A9MAPTALDH1A1LMNA | |
| SCHEMBL7086602 | 0.81 | TOP2A (0.34) | EPHX1SLC6A9MAPTALDH1A1LMNA | |
| SCHEMBL6972949 | 0.81 | ALOX12 (0.37) | SLC6A9DHFRSMN1; SMN2 | |
| SCHEMBL7081810 | 0.81 | CA2 (0.38) | EPHX1SLC6A9MAPTALDH1A1LMNA | |
| SCHEMBL7078713 | 0.81 | S1PR3 (0.39) | EPHX1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |