Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960209 | 0.77 | PLK1 (0.48) | MAPTPLK1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL4239653 | 0.74 | AR (0.54) | MAPTSMN1; SMN2LMNANPSR1TDP1 | |
| SCHEMBL22927645 | 0.73 | TSHR (0.48) | MAPTALDH1A1TSHR | |
| SCHEMBL29434770 | 0.73 | TSHR (0.48) | MAPTALDH1A1TSHR | |
| SCHEMBL23558108 | 0.71 | SMN1; SMN2 (0.59) | MAPTPLK1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6964975 | 0.71 | PLK1 (0.42) | MAPTPLK1LMNANPSR1TDP1 | |
| SCHEMBL6964973 | 0.71 | PLK1 (0.40) | PLK1LMNANPSR1TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29908241 | 0.71 | TSHR (0.46) | MAPTALDH1A1TSHR | |
| SCHEMBL4296254 | 0.69 | AR (0.42) | MAPTSMN1; SMN2LMNANPSR1TDP1 | |
| SCHEMBL6972135 | 0.69 | MEN1 (0.47) | MAPTPLK1SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |