Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706123 | 0.87 | NPC1 (0.37) | CES2CES1NPC1RAB9AF2RL1 | |
| SCHEMBL10957602 | 0.83 | CA12 (0.38) | PARP1NPC1RAB9ACYP3A4KMT2A | |
| SCHEMBL697332 | 0.81 | NPC1 (0.54) | CES2CES1PARP1PAK4ALPL | |
| SCHEMBL1573195 | 0.81 | NPC1 (0.46) | PARP1HDAC6NPC1RAB9AKMT2A | |
| SCHEMBL696226 | 0.81 | KMT2A (0.41) | PARP1PAK4NPC1RAB9AKMT2A | |
| SCHEMBL696858 | 0.81 | CES2 (0.45) | CES2NPC1RAB9AKCNQ3KCNQ2 | |
| SCHEMBL697210 | 0.80 | NPC1 (0.42) | NPC1RAB9AF2RL1 | |
| SCHEMBL697784 | 0.80 | MTOR (0.47) | NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL1573433 | 0.79 | KMT2A (0.37) | CES2CES1NPC1RAB9AF2RL1 | |
| SCHEMBL27826895 | 0.78 | LOXL2 (0.44) | NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| CN-101370786-B | Substituted imidazoles and their use as pesticides | PFIZER | 2012-01-11 | — | — | CN | disclosed |
| EP-1981853-B1 | SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES | PFIZER LTD (GB) | 2011-04-13 | — | — | EP | disclosed |