Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962477 | 0.84 | PHF8 (0.48) | PHF8NPC1SIGMAR1KDM4CCYP11B1 | |
| SCHEMBL6952807 | 0.80 | SIGMAR1 (0.45) | PHF8SIGMAR1KDM4CCYP11B1CYP11B2 | |
| SCHEMBL6974015 | 0.79 | PHF8 (0.37) | PHF8KDM4CCYP11B1CYP11B2CYP2A6 | |
| SCHEMBL6968098 | 0.79 | PHF8 (0.37) | PHF8KDM4CCYP11B1CYP11B2CYP2A6 | |
| SCHEMBL15015629 | 0.77 | HDAC1 (0.57) | CNR1HDAC1HDAC6SIGMAR1CYP3A4 | |
| SCHEMBL6968013 | 0.75 | KDM4C (0.40) | PHF8NPC1RAB9AKDM4CCYP11B1 | |
| SCHEMBL6955809 | 0.73 | HPGDS (0.39) | PHF8SIGMAR1KDM4CCYP11B1CYP11B2 | |
| SCHEMBL6972346 | 0.72 | PHF8 (0.38) | PHF8NPC1RAB9ASIGMAR1KDM4C | |
| SCHEMBL30741761 | 0.72 | HPGDS (0.50) | PHF8NPC1RAB9ASIGMAR1KDM4C | |
| SCHEMBL9023871 | 0.71 | SIGMAR1 (0.44) | PHF8SIGMAR1KDM4CCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |