Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962492 | 0.95 | TLR8 (0.33) | TLR8TLR7SLC18A3ALDH1A1MEN1 | |
| SCHEMBL7084963 | 0.92 | ALDH1A1 (0.34) | SLC18A3ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL6960981 | 0.89 | TLR8 (0.33) | TLR8TLR7ALDH1A1TDP1 | |
| SCHEMBL6974348 | 0.86 | GSK3B (0.34) | TLR8TLR7MEN1KMT2ATDP1 | |
| SCHEMBL6972831 | 0.84 | TDP1 (0.32) | TLR8TDP1 | |
| SCHEMBL6975492 | 0.84 | HRH4 (0.35) | MEN1KMT2ATDP1 | |
| SCHEMBL6974526 | 0.84 | TDP1 (0.32) | TLR8TLR7ALDH1A1TDP1 | |
| SCHEMBL6972963 | 0.83 | GSK3B (0.38) | TLR7TDP1 | |
| SCHEMBL6973948 | 0.82 | LMNA (0.42) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL6970187 | 0.82 | LMNA (0.44) | ALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |