Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973716 | 0.93 | HSP90AA1 (0.36) | MAPTKDM4ETP53HSP90AA1HSP90B1 | |
| SCHEMBL7135439 | 0.87 | CFTR (0.40) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL7082472 | 0.87 | ALDH1A1 (0.37) | MAPTKDM4ETP53NPC1RAB9A | |
| SCHEMBL6974458 | 0.86 | S1PR3 (0.38) | KDM4ERAB9AENPP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6965073 | 0.86 | MAPT (0.35) | MAPTTP53NPC1RAB9AGRIN1 | |
| SCHEMBL6969739 | 0.85 | POLB (0.38) | MAPTTP53NPC1RAB9AGRIN1 | |
| SCHEMBL6974023 | 0.85 | TLR8 (0.36) | MAPTKDM4ETP53RAB9AGRIN1 | |
| SCHEMBL8507295 | 0.85 | HRH3 (0.39) | MAPTKDM4ETP53GRIN1GRIN2B | |
| SCHEMBL6967528 | 0.85 | GRM5 (0.36) | MAPTKDM4ETP53GRIN1GRIN2B | |
| SCHEMBL7079929 | 0.85 | GRM5 (0.38) | MAPTKDM4ETP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |