Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 10/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344845 | 0.93 | PKM (0.41) | LMNAHDAC6TBXAS1ENPP2GRIN1 | |
| SCHEMBL8342977 | 0.90 | LMNA (0.45) | LMNAHDAC6TBXAS1ENPP2RXFP1 | |
| SCHEMBL6969096 | 0.89 | LMNA (0.42) | LMNAHDAC6TBXAS1ENPP2TBXA2R | |
| SCHEMBL8343038 | 0.89 | TBXA2R (0.42) | LMNAENPP2TBXA2RRXFP1 | |
| SCHEMBL6975018 | 0.89 | GRIN1 (0.38) | ENPP2GRIN1GRIN2BTBXA2RPKM | |
| SCHEMBL7086853 | 0.87 | GRIN1 (0.37) | ENPP2GRIN1GRIN2BPKM | |
| SCHEMBL6973823 | 0.87 | GRIN1 (0.38) | GRIN1GRIN2BPKM | |
| SCHEMBL6972580 | 0.87 | GRIN1 (0.36) | ENPP2GRIN1GRIN2BPKM | |
| SCHEMBL6969539 | 0.87 | GRIN1 (0.39) | GRIN1GRIN2B | |
| SCHEMBL6974966 | 0.86 | GRIN1 (0.36) | ENPP2GRIN1GRIN2BPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |