Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697293 | 0.91 | P2RX7 (0.45) | P2RX7THRBALOX12KMT2ATAAR1 | |
| SCHEMBL696508 | 0.87 | ACE (0.44) | CA2CA1ACEALDH1A1SMN1; SMN2 | |
| SCHEMBL3717614 | 0.72 | MMP8 (0.53) | THRBALOX12KMT2AEPHX2ALDH1A1 | |
| SCHEMBL3716347 | 0.69 | ACE (0.49) | ACEMAPT | |
| SCHEMBL2107446 | 0.69 | CTSS (0.46) | P2RX7KMT2AEPHX2 | |
| SCHEMBL26124386 | 0.68 | P2RX7 (0.59) | P2RX7THRBALOX12KMT2AACE | |
| SCHEMBL26124183 | 0.68 | P2RX7 (0.59) | P2RX7THRBALOX12KMT2AACE | |
| SCHEMBL3718817 | 0.67 | ACE (0.40) | ACEALDH1A1 | |
| SCHEMBL696406 | 0.66 | ALDH1A1 (0.48) | P2RX7TAAR1EPHX2ACEALDH1A1 | |
| SCHEMBL10799355 | 0.65 | ACE (0.49) | ACEALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |